In collaboration with the University of Tokyo, researchers in AIST have shown that, by removing essential bacterial symbiont from the stinkbugs, infecting fast-evolving E. coli instead, and maintaining the symbiont-replaced stinkbugs continuously in the laboratory, E. coli can evolve into an essential symbiont that supports the survival of the host stinkbugs within a short period of time, ranging from a few months to a year, through a single mutation that disrupts a global transcriptional regulatory system.
This study demonstrated that the evolution of symbiotic microorganisms, which are essential for host survival, can occur more rapidly and easily than previously envisaged. It was groundbreaking that we successfully made E. coli, the best-studied model bacterium in molecular biology, evolve into a symbiotic bacterium. Using this insect-E. coli experimental symbiotic system, it is expected to greatly advance our understanding of the processes and mechanisms of symbiotic evolution in the future.
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