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Department of Life Science and Biotechnology

Realizing a healthy, active, aged society and creating a sustainable society

A society in which people live a long life in good health and at ease, and a sustainable society with reduced environmental load is desired. We are contributing to life innovation by developing new technologies to evaluate health and to promote drug discovery, as well as to maintain, improve, and recover health according to individual conditions. We are also contributing to green innovation by developing technologies to reduce environmental loads using bioprocesses.

 
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New Research Results

Development of New Mouse Model for Early Stage of Alzheimer's Disease

AIST developed a novel mouse model of Alzheimer's disease (AD). The developed AD model mice are transgenic mice (Aβ-GFP mice) that express only oligomers of amyloid-β protein (Aβ), one of the causative factors of AD, in neurons and exhibit early stage of AD.

Figure of new research results Life Science and Biotechnology

Development of Aβ-GFP mice expressing oligomers of Aβ-GFP fusion protein (schematic diagram, left). Aβ oligomers are strongly expressed in neurons in the hippocampus and the cerebral cortex of the brain (right).

Elucidation of the Mechanism of Dry Environment Resistance via Ant Neuropeptide

AIST examined the expression levels of inotocin, an ant neuropeptide, between young worker ants staying the nest and old worker ants active outside. It was clarified that inotocin controls the synthesis of hydrocarbons that prevent the water loss from the body surface.

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Worker ant with individual identification barcode (left) and the mechanism to regulate the resistance against the dry environment via inotocin (right)

Research Unit

Open Innovation Laboratory

Since FY 2016, as a part of the “Open Innovation Arena concept” promoted by the Ministry of Economy, Trade and Industry (METI), AIST has created the concept of “open innovation laboratories” (OILs), collaborative research bases located on university campuses, and has been engaged in their provision. We are planning to establish more than ten OILs by FY 2020.

AIST will merge the basic research carried out at universities, etc. with AISTʼs goal-oriented basic research and applied technology development, and will promote bridging research and evelopment and industry by the establishment of OILs.

  • AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL)
  • AIST-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory (PhotoBIO-OIL)

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