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Update(MM/DD/YYYY):03/18/2019

Elucidating the Cause of Chromosomal Abnormalities Induced by Calcium Ion Deficiency

– Contributing to elucidation of the mechanism by which organisms maintain their genome stably –


Researchers: Takata Hideaki, Senior Researcher, the Medical and Biological Engineering Research Group, the Biomedical Research Institute

Summary

The researcher has clarified the mechanism by which abnormalities occur in the structure of chromosomes built during cell division.

Figure 1
Model of chromosomal abnormality induction by calcium ion deficiency



Background

Chromosome structure is formed during cell division, and DNA is distributed to daughter cells to transmit genetic information. While it was known that abnormalities can be found in the structure of chromosomes and cell division is not performed normally when there is a calcium ion deficiency, the mechanism behind this was unclear. Therefore, the researcher investigated the effect of calcium ions on chromosome structure during the cell division phase.

Mechanism clarified by the researcher

The researcher showed that chromosome structural abnormalities are caused by the destabilization of kinetochore microtubules composed of chromosome kinetochores and microtubules. Furthermore, they showed that this destabilization is caused by the loss of CENP-F, one of the kinetochore proteins with the role of connecting kinetochores and microtubules, due to the decreased calcium ion concentration.

Future Research Plans

By clarifying the mechanism by which calcium ions act on CENP-F, the researchers will contribute to the elucidation of the mechanism by which organisms maintain their genome stably.







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