Vol.8 No.2 2015

Research paper : Detection of influenza viruses with the waveguide mode sensor (K. AWAZU et al.)−107−Synthesiology - English edition Vol.8 No.2 (2015) technologies, where there were hardly any overlaps, was necessary. By conducting joint research with the experts of surface chemistry and virology, we succeeded in developing the intermediate integrated technologies. Toward our goal, we returned to the elemental technologies several times, optimized the intermediate integrated technologies, and constructed the integrated technology. I added such a description to subchapter 3.4 “Synthesiological discussion.” I also added chapter 4 “Process for the fusion of different fields” for the general evaluation and future prospects, to match the objective of Synthesiology.3 Superiority of the performanceComment (Yasushi Mitsuishi)Since it is already widely known that the specificity of antigen-antibody reaction is extremely high, in this paper, I think the objective will be achieved if you thoroughly describe the work on sensor design to introduce the wavelength sweeping property without sacrificing the sensitivity of the angle sweeping detector, as well as the implementations done to the palmtop device that will make it appropriate for on-site use. Also, please organize the descriptions so you can clearly convey the superiority of the device that can detect influenza virus subtypes precisely, quickly, with high sensitivity compared to the detection methods using the conventional antigen-antibody reaction.Answer (Koichi Awazu)Since the concept of shifting from angle sweep to wavelength sweep is difficult to communicate to the readers, I added Fig. 2 that shows the results of the new calculation. I think this figure will help three-dimensional understanding of waveguide modes that appear in the respective sweeping method. The superiority of this method against the conventional ones is shown in Table 2, with the description of sensitivity and measurement time.4 Response to the result of this researchComment (Naoto Kobayashi)In this research, you have developed an innovative method from the perspective of simplification and quickness, compared to the conventional methods that require a long period of time for preliminary treatment and measurement and yet have low sensitivity. I believe the research results have attracted much attention of persons concerned, but how are their responses? If you have any comments or evaluations from such parties, please mention them.Answer (Koichi Awazu)As the social issue for which the sensor that we fabricated would be used, we received suggestions from an internist for a quick testing device for new strains of influenza. In 2008, the internist commented that if a pandemic of a new strain of influenza occurred, they would be helpless as physicians because the PCR technology at the time took too long and the immuno-chromatography could not determine whether the virus was a new strain. I think we can respond to the urgent social demands for quick, on-site identification of new strains of influenza using this sensor. I added this point in chapter 4 “Process of the fusion of different fields.”


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