Vol.8 No.2 2015

Research paper : Detection of influenza viruses with the waveguide mode sensor (K. AWAZU et al.)−106−Synthesiology - English edition Vol.8 No.2 (2015) Researcher, Telecommunications Advancement Organization of Japan, participated in Femtosecond Technology Research Association in 2000 and engaged in the research for ultra high-speed optical transmission. Engaged in the development of new optical device at the Center for Applied Near-Field Optics Research, AIST in 2003-2010. Transferred to the Nanoelectronics Research Institute, AIST and engaged in the research of new phase-change functional devices. Doctor of Engineering, Waseda University in 2011. In this paper, conducted the numerical calculation of magnetic wave and the optical design for achieving high sensitivity.AuthorsKoichi AWAZUCompleted the doctorate course at Tokyo Institute of Technology in 1991. Doctor (Engineering). Joined the Electrotechnical Laboratory in 1991, and engaged in research of accelerator application engineering. Visiting Researcher, Université de Montréal, Quebéc, Canada in 1996-1998; Senior Researcher, New Energy and Industrial Technology Development Organization (NEDO) in 2001-2002; Visiting Professor, Institute for Molecular Science in 2002-2004; Team Leader, Center for Applied Near-Field Optics Research, AIST in 2003-2010; Visiting Professor, Faculty of Engineering, The University of Tokyo in 2005-2007; Director, Research Planning Office of Information Technology and Electronics, AIST in 2009-2012; and Deputy Director, Electronics and Photonics Research Institute, AIST from 2012. Engages in research for nanophotonics and fused discipline with medicine. In this paper, investigated the observation of interface and surface states.Makoto FUJIMAKICompleted the doctorate course at Waseda University in 1998. Doctor (Engineering). Engaged in the research for optical communication devices at Waseda University and Université de Montréal on Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists. Engaged in the development of power electronics devices and optical communication elements at the Electrotechnical Laboratory as Domestic Research Fellow, Japan Science and Technology Corporation. After taking position as Associate Professor of Waseda University, joined AIST in 2004. Chief Planner, Research Planning Office of Information Technology and Electronics, AIST in 2012-2013; and Group Leader, Optical Sensing Group, Electronics and Photonics Research Institute in 2013 to present. Works on the development of biosensing technology using near-field optics. Appointed director of the AIST Technology Transfer Venture, and works on the practical application of technologies developed at AIST. In this paper, engaged mainly on the optical design.Subash C. B. GOPINATHCompleted the doctorate course at University of Madras, India in 1999. Joined the Academia Sinica, Taiwan in 1999; post-doctoral researcher and technical staff, AIST in 2003-2013; and Associate Professor, Institute of Nano Electronic Engineering, University Malaysia Perlis in 2013 to present. Engages in research of fused disciplines of bioscience and nanotechnology. In this paper, was in charge of overall virus detection.Xiaomin WANG Withdrew from the doctorate course at the Department of Electronic Engineering, Graduate School of Engineering, The University of Tokyo in 1999. After working as Visiting Discussions with Reviewers1 OverallComment (Naoto Kobayashi, Center for Research Strategy, Waseda University)This paper is a report on the R&D of a device that enables simple and quick identification of the influenza virus by detecting the changes in light reflection spectrum using the waveguide mode sensor. It is a detailed description of a process by which an extremely useful method for solving an urgent health and medical issue of society was created. It is an excellent case of innovative creation, and the content is appropriate for Synthesiology.However, since the first draft was a review of the authors’ published papers shown in the references, and I suggested restructuring the paper as a description of innovation methodology. As a result, the objective, scenario, elemental technologies, and their syntheses were described in an organized manner, and the paper became appropriate for Synthesiology.Comment (Yasushi Mitsuishi, AIST)This paper is about the size reduction of a virus detector using the waveguide mode sensor that can sensitively detect the adsorption of nanoparticles, and the company to which the technology was transferred has developed a palmtop device for practical use. This is a paper befitting Synthesiology. However, the first draft of the paper spent much space on the presentation of detection data based on the antigen-antibody reaction, and there was very little description about what kind of work was done to reduce the device size or how it was made usable for on-site use. I felt that the goals of the paper were not sufficiently explained.2 Synthesiological discussionComment (Naoto Kobayashi)In Synthesiology, you are required to describe the goal of research, the scenario to achieve the goal, the selection and integration of elements (elemental technologies) to achieve the goal, and the evaluation of the results. Please present a figure that enables ready understanding of the relationship of the above, and describe the relationships of the elemental technologies, intermediate integrated technologies, and the integrated technology (goal) of this research. Also, please describe the general evaluation and future prospects for the R&D method for simplified and quick influenza virus detection.Answer (Koichi Awazu)I added Fig. 12 as a synthesiological diagram. The “realization of simple and highly sensitive influenza virus detector” is the demand and the goal. On the other hand, we already have significant accumulation of elemental technologies of silicon technology, optics, and electromagnetics. To achieve an integrated technology, the fusion of the four fields of elemental


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