Vol.8 No.2 2015

Research paper : Detection of influenza viruses with the waveguide mode sensor (K. AWAZU et al.)−104−Synthesiology - English edition Vol.8 No.2 (2015) joint research with the experts of surface chemistry and virology, we succeeded in developing an intermediate integrated technology. Toward our goal, we returned to the elemental technologies several times, optimized the intermediate integrated technologies, and constructed the integrated technology.4 Process of the fusion of different fieldsIn this research, the cooperation of the researchers of optical experiment and calculation was necessary to design and fabricate the palmtop sensor. Moreover, we needed cooperation of the companies to realize the design. As the social issue for which the sensor that we fabricated could be used, we received suggestions from an internist for a quick testing method for new strains of influenza. In 2008, the internist commented that if a pandemic of a new strain of influenza occurred, they would be helpless as physicians because the PCR technology at the time took too long and the immuno-chromatography could not determine whether a virus was a new strain. This was one year before the spring of 2009 when a new strain of influenza broke out in Mexico and developed into a pandemic. We believe we can respond to the urgent social demand for quick, on-site identification of new strains of influenza using this sensor. The most important point in observing the surface reaction was the inhibition of nonspecific adsorption. Although there were no descriptions about inhibiting nonspecific adsorption in most papers, it was an important issue in measuring viruses in samples. This was solved through joint research with the Biomedical Research Institute within AIST. This research was achieved through the collaboration of information and technical elements of the researchers in different fields.5 ConclusionTo achieve a safe and secure society in the future, we think it is necessary to be able to detect various viruses, not just of influenza. Since there is no boundary for viral infection, it is necessary for each country to regularly and carefully monitor the viruses and stop the virus spread at the border. Although it is said that virus infection and temperature, humidity, and bacteria are related, the whole picture is not yet clear. By managing all data with geographical information, it can be developed into a new business such as IT medicine or IT agriculture. In such a case, rather than selling a sensor as a product, there is a possibility for business of packaging the product with service, information, and maintenance.In this paper, the content was specifically on the detection of influenza viruses. Currently, we are developing a simplified blood testing device using waveguide mode sensors, and we aim to determine the presence of infectious diseases such as B or C type hepatitis as well as blood types. If this can be achieved, it may be possible to provide blood transfusion at refugee shelters in disaster areas or conduct blood tests in ambulances. Also, since it is a system to observe surface reaction, it can be used in the management of production lines such as in the continuous monitoring for deterioration of plating solutions. Several companies that operate plating plants have already shown interest in this application.AcknowledgementIn this R&D, the students of Professor Yoshimichi Ohki’s Laboratory, Faculty of Science and Engineering, Waseda Silicon technologyVirologySurface chemistryOptics and electromagneticsIdentification of influenza sub-speciesDevelopment of nonspecific adsorption inhibited surfaceSize reduction of sensorIntegrated technologyIntermediate integrated technologiesElemental technologiesRealization of simplified and highly sensitive influenza virus detector(a)(b)(c)Nonspecific adsorption inhibitionFig. 11 Nonspecific adsorption inhibiting surfaceTriethoxysilane was bonded with (a) methoxy oligoethyleneglycol and (b) succinimide ester. The (a) inhibited nonspecific adsorption, and (b) of the succinimide group bonded with the carbonyl group of antibodies.Fig. 12 Synthesiological description


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