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Research paper : Research and development of a monopivot centrifugal blood pump for clinical use (T. Yamane et al.)−23−Synthesiology - English edition Vol.5 No.1 (2012) [4]O.Maruyama, M.Nishida, T.Tsutsui, T.Jikuya and T.Yamane: The hemolytic characteristics of monopivot magnetic suspension blood pumps with washout holes, Artificial Organs, 29.(4), 345-348 (2005).[5]M.Nishida, O.Maruyama, R.Kosaka, T.Yamane, H.Kogure, H.Kawamuras, Y.Yamamoto, K.Muwana, Y.Sankai and T.Tsutsui: Hemocompatibility evaluation with experimental and computational fluid dynamic analysis for a monopivot circulatory assist pump, Artificial Organs, 33 (4), 378-386 (2009).[6]T.Yamane, O.Maruyama, M.Nishida, M.Toyoda, T.Tsutsui, T.Jikuya, O.Shigeta and Y.Sankai: The most profitable use of flow visualization in the elimination of thrombus from a monopivot magnetic suspension blood pump, Artificial Organs, 28 (4), 390-397 (2004).[7]O.Maruyama, Y.Tomari, D.Sugiyama, M.Nishida, T. Tsustui and T.Yamane: Simple in vitro testing method for antithrombogenic evaluation of centrifugal blood pumps, ASAIO Journal, 55 (4), 314-322 (2009).AuthorsTakashi YamaneCompleted the doctorate course at the Department of Aeronautics, Graduate School of Engineering, the University of Tokyo in 1980. Joined the Mechanical Engineering Laboratory, Agency of Industrial Science and Technology, Ministry of International Trade and Industry in 1980. Joined AIST in 2001 as it was reorganized, was deputy director of the Institute for Human Science and Biomedical Engineering. Became visiting professor of the Cooperation Program of Graduate School of the School of Science and Technology, Tokyo University of Science in 2001. For two years from 2007, worked as secretariat of the project, R&D Guideline for Innovative Artificial Heart Systems, Ministry of Economy, Trade and Industry. For two years from 2008, sent to the Pharmaceuticals and Medical Devices Agency as a specialist. Returned to AIST in 2010, Prensently, principal research scientist of the Human Technology Research Institute. Received Achievement Award from the Bioengineering Division of the Japan Society of Mechanical Engineers in 2009., In this paper, was in charge of proposal for pump mechanism, experiments of fluid characteristics and bearing characteristics, animal experiments, and overall management of collaborative research with a company. Doctor of Engineering.Osamu MaruyamaCompleted Department of Biosignal Research at the Graduate School of Medicine, Gunma University in 1995. Joined the Mechanical Engineering Laboratory, Agency of Industrial Science and Technology, Ministry of International Trade and Industry in 1995. Joined AIST in 2001 as it was reorganized, was senior researcher of the Artificial Organ Group, Institute for Human Science and Biomedical Engineering. For a year from 2003, worked as senior officer of the Planning Headquarters, and from 2010, as leader of the Artificial Organ Group, Human Technology Research Institute of AIST. Received Best Paper Award from Japanese Society for Artificial Organs. For this paper, was in charge of blood compatibility evaluation test of the pump and animal experiments. Doctor of Medicine.Masahiro NishidaCompleted the doctoral program of the Graduate School of Science and Technology, Keio University in 1995. Joined the Mechanical Engineering Laboratory, Agency of Industrial Science and Technology, Ministry of International Trade and Industry in 1995. Senior researcher, Biomimetics Laboratory from 1999. For 6 months in 2000, worked at the Medical and Assistive Devices Office, Agency of Industrial Science and Technology, Ministry of International Trade and Industry. For a year in 2000, visiting researcher at Charité University Hospital of the Humboldt University of Berlin. Returning to Japan, worked for 10 months at Academia Industry Cooperation Promotion Office, Industrial Science and Technology Policy and Environment Bureau, Ministry of Economy, Trade and Industry. Joined AIST in 2001 as it was reorganized, Senior researcher of the Artificial Organ Group, Institute for Human Science and Biomedical Engineering. For a year in 2009, part-time lecturer, the National University Corporation of Tsukuba University of Technology. At present, senior researcher of the Artificial Organ Group, Human Technology Research Institute of AIST. In this paper, was in charge of mic experiment and computational fluid dynamic analysis. Doctor of Engineering.Ryo KosakaIn 2003, special researcher (DC2), Japan Society for the Promotion of Science. Completed doctoral program of the Graduate School of Systems and Information Engineering, University of Tsukuba. Joined AIST in 2005, was researcher of the Institute for Human Science and Biomedical Engineering. From 2010, researcher of the Artificial Organ Group, Human Technology Research Institute of AIST. In this paper, was in charge of system control and status monitoring/sensing. Doctor of Engineering.Discussions with Reviewers1 Overall structureComment (Motoyuki Akamatsu: Human Technology Research Institute, AIST)The purpose of Synthesiology is to publish papers that allow readers to gain knowledge of how to poceed with research. It is expected that the papers would explain, for example, at what timing of the research and development process the researcher decided on what was needed, to what the attention would be given and what were the reasons behind the decisions. With this in mind, in chapter 2, goal setting a goal is mentioned, but is it possible to write about the scenario of what kind of development was to be conducted for that goal? Answer (Takashi Yamane)In chapter 2, we explain the logic of research, and extract the important phenomena of designing for “2.Research of a monopivot centrifugal blood pump.” In chapter 3, we point to the revision of target of product development as “3, Reset of the goal

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