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Research paper : Development of basic tools for glycoscience and their application to cancer diagnosis (H. Narimatsu)−212−Synthesiology - English edition Vol.5 No.3 (2012) H. Mochizuki, N. Inaba, A. Togayachi, T. Kudo, H. Watanabe, K. Kimata and H. Narimatsu: Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine, J. Biol. Chem., 277(41), 38179-38188 (2002).[7]J.M. Guo, Y. Zhang, L. Cheng, H. Iwasaki, H. Wang, T. Kubota, K. Tachibana and H. Narimatsu: Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12, FEBS Lett., 524(1), 211-218 (2002).[8]T. Hiruma, A. Togayachi, K. Okamura, T. Sato, N. Kikuchi, YD. Kwon, A. Nakamura, K. Fujimura, M. Gotoh, K. Tachibana, Y. Ishizuka, T. Noce, H. Nakanishi and H. Narimatsu: A novel human 1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc1-3GlcNAc, J. Biol. Chem., 279(14), 14087-14095 (2004).[9]N. Inaba, T. Hiruma, A. Togayachi, H. Iwasaki, XH. Wang, Y. Furukawa, R. Sumi, T. Kudo, K. Fujimura, T. Iwai, M. Gotoh, M. Nakamura and H. Narimatsu: A novel I-branching -1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression, Blood, 101(7), 2870-2876 (2003).[10]H. Ishida, A. Togayachi, T. Sakai, T. Iwai, T. Hiruma, T. Sato, R. Okubo, N. Inaba, T. Kudo, M. Gotoh, J. Shoda, N. Tanaka and H. Narimatsu: A novel 1,3-N-acetylglucosaminyltransferase (3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer, FEBS Lett., 579(1), 71-78 (2005).[11]T. Iwai, N. Inaba, A. Naundorf, Y. Zhang, M. Gotoh, H. Iwasaki, T. Kudo, A. Togayachi, Y. Ishizuka, H. Nakanishi and H. Narimatsu: Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide 1,3-N-acetylglucosaminyltransferase (3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans, J. Biol. Chem., 277(15), 12802-12809 (2002).[12]T. Iwai, T. Kudo, R. Kawamoto, T. Kubota, A. Togayachi, T. Hiruma, T. Okada, T. Kawamoto, K. Morozumi and H. Narimatsu: Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells, Proc. Natl. Acad. Sci., 102(12), 4572-4577 (2005).[13]N. Kikuchi, A. Kameyama, S. Nakaya, H. Ito, T. Sato, T. Shikanai, Y. Takahashi and H. Narimatsu: The carbohydrate sequence markup language (CabosML): an XML description of carbohydrate structures, Bioinformatics, 21(8), 1717-1718 (2005).[14]N. Kikuchi, YD. Kwon, M. Gotoh and H. Narimatsu: Comparison of glycosyltransferase families using the profile hidden Markov model, Biochem. Biophys. Res. Commun., 310(2), 574-579 (2003).[15]T. Kudo, T. Iwai, T. Kubota, H. Iwasaki, Y. Takayama, T. Hiruma, N. Inaba, Y. Zhang, M. Gotoh, A. Togayachi and H. Narimatsu: Molecular cloning and characterization of a novel UDP-Gal:GalNAc() peptide 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan, J. Biol. Chem., 277(49), 47724-47731 (2002).[16]H. Mochizuki, K. Yoshida, M. Gotoh, S. Sugioka, N. Kikuchi, YD. Kwon, A. Tawada, K. Maeyama, N. Inaba, T. Hiruma, K. Kimata and H. Narimatsu: Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide, J. Biol. Chem., 278(29), 26780-26787 (2003).[17]H. Narimatsu: Construction of a human glycogene library and comprehensive functional analysis, Glycoconj. J., 21(1-2), 17-24 (2004).[18]H. Narimatsu: Human glycogene cloning: focus on 3-glycosyltransferase and 4-glycosyltransferase families, Curr. Opin. Struct. Biol., 16(5), 567-575 (2006).[19]C. Peng, A. Togayachi, YD. Kwon, C. Xie, G. Wu, X. Zou, T. Sato, H. Ito, K. Tachibana, T. Kubota, T. Noce, H. Narimatsu and Y. Zhang: Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile, Biochem. Biophys. Res. Commun., 402(4), 680-686 (2010).[20]T. Sato, M. Gotoh, K. Kiyohara, T. Akashima, H. Iwasaki, A. Kameyama, H. Mochizuki, T. Yada, N. Inaba, A. Togayachi, T. Kudo, M. Asada, H. Watanabe, T. Imamura, K. Kimata and H. Narimatsu: Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate, J. Biol. Chem., 278(5), 3063-3071 (2003).[21]T. Sato, M. Gotoh, K. Kiyohara, A. Kameyama, T. Kubota, N. Kikuchi, Y. Ishizuka, H. Iwasaki, A. Togayachi, T. Kudo, T. Ohkura, H. Nakanishi and H. Narimatsu: Molecular cloning and characterization of a novel human 1,4-N-acetylgalactosaminyltransferase, 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc 1-4GlcNAc, J. Biol. Chem., 278(48), 47534-47544 (2003).[22]T. Sato, M. Sato, K. Kiyohara, M. Sogabe, T. Shikanai, N. Kikuchi, A. Togayachi, H. Ishida, H. Ito, A. Kameyama, M. Gotoh and H. Narimatsu: Molecular cloning and characterization of a novel human 1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain, Glycobiology, 16(12), 1194-1206 (2006).[23]A. Togayachi, T. Akashima, R. Ookubo, T. Kudo, S. Nishihara, H. Iwasaki, A. Natsume, H. Mio, J. Inokuchi, T. Irimura, K. Sasaki and H. Narimatsu: Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide 1,3-N-acetylglucosaminyltransferase (3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids, J. Biol. Chem., 276(25), 22032-22040 (2001).[24]A. Togayachi, N. Kikuchi, T. Kudo and H. Narimatsu: Comprehensive study on glycosyltransferases which determine glycosylation, Tanpakushitsu Kakusan Koso, 48(11 Suppl), 1542-1549 (2003).[25]A. Togayachi, T. Sato and H. Narimatsu: Comprehensive enzymatic characterization of glycosyltransferases with a 3GT or 4GT motif, Methods Enzymol., 416, 91-102 (2006).[26]H. Wang, K. Tachibana, Y. Zhang, H. Iwasaki, A. Kameyama, L. Cheng, JM. Guo, T. Hiruma, A. Togayachi, T. Kudo, N. Kikuchi and H. Narimatsu: Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14, Biochem. Biophys. Res. Commun., 300(3), 738-744 (2003).[27]T. Yada, M. Gotoh, T. Sato, M. Shionyu, M. Go, H. Kaseyama, H. Iwasaki, N. Kikuchi, YD. Kwon, A. Togayachi, T. Kudo, H. Watanabe, H. Narimatsu and K. Kimata: Chondroitin sulfate synthase-2: molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities, J. Biol. Chem., 278(32), 30235-30247 (2003).[28]T. Yada, T. Sato, H. Kaseyama, M. Gotoh, H. Iwasaki, N. Kikuchi, YD. Kwon, A. Togayachi, T. Kudo, H. Watanabe, H.

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