Vol.3 No.1 2010

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Research paper : Biomarker analysis on microchips (M. Kataoka et al.)−50−Synthesiology - English edition Vol.3 No.1 (2010) AuthorsMasatoshi KataokaCompleted the course at the Graduate School of Dentistry, The University of Tokushima in 1990. Doctor of Dentistry. Worked as a dentist specializing in periodontal disease at the Faculty of Dentistry, The University of Tokushima from 1990 to 2002, and studied the genetic analysis of the periodontal pathogenic factor. Engaged in research for the biological analysis using the microchip electrophoresis as an associate professor of genetic expression field at the Institute for Genome Research, The University of Tokushima until 2004. Joined the Health Technology Research Center, AIST Shikoku as a senior researcher in 2006. Leader of Biomarker Analysis Team from 2007. Leader of Biomarker Analysis Group, Health Research Institute, AIST from 2010. Works on application of the microchip to biomarker analysis including electrophoresis. In this paper, constructed the biological analysis method using the microchip and coordinated the overall concept.[5][6][7][8][9][10][11][12][13]of nonstandard DNA samples and subsequent on-chip enzymatic digestion, Eur. J. Biochem. 271, 2241-2247 (2004).M. Kataoka, Y. Fukura, Y. Shinohara and Y. Baba: Analysis of mitochondrial membrane potential in the cells by microchip flow cytometry, Electrophoresis 26, 3025-3031 (2005).Y. Umemoto, M. Kataoka, S. Yatsushiro, M. Watanabe, J. Kido, R. Kakuhata, Y. Shinohara and Y. Baba: Sequential analysis of RNA synthesis by microchip electrophoresis, Anal. Biochem. (in press).R. Akamine, S. Yatsushiro, S. Yamamura, J. Kido, Y. Shinohara, Y. Baba and M. Kataoka: Direct endonuclease digestion and multi-analysis of restriction fragment length polymorphisms by microchip electrophoresis, J. Pharm. Biomed. Anal. (in press).Y. Umemoto, M. Kataoka, S. Yatsushiro, S. Yamamura, T. Ooie, J. Kido, T. Yamamoto, Y. Shinohara and Y Baba: Analysis of DNA ligation by microchip electrophoresis, J. Pharm. Biomed. Anal. (in press).E. Maeda, M. Kataoka, M. Hino, K. Kajimoto, N. Kaji, M. Tokeshi, J. Kido, Y. Shinohara and Y. Baba: Determination of human blood glucose levels using microchip electrophoresis, Electrophoresis 28, 2927-2933 (2007).E. Maeda, M. Kataoka, S. Yatsushiro, K. Kajimoto, M. Hino, N. Kaji, T. Tokeshi, M. Bando, J. Kido, M. Ishikawa, Y. Shinohara and Y. Baba: Accurate quantitation of salivary and pancreatic amylase activities in human plasma by microchip electrophoretic separation of the substrates and hydrolysates coupled with immunoinhibition, Electrophoresis 29, 1902-1909 (2008).E. Maeda, K. Hirano, Y. Baba, H. Nagata and M. Tabuchi: Conformational separation of monosaccharides of glycoproteins labeled with 2-aminoacrydone using microchip electrophoresis, Electrophoresis 27, 2002-2010 (2006).T. Kawai, Y. Ito, I. Sakurabayashi, M. Ogata, T. Mikuni, S. Kimura, A. Sakurai, H. Kamoi and O. Sugita: Ijochi No Deru Mekanizumu (Mechanism by which Abnormal Values Occur), 287-290, Igaku Shoin, Tokyo (2005) (in Japanese).P. R. Ebeling, J. M. Peterson and B. L. Riggs: Utility of type I procollagen propeptide assay for assessing abnormalities in metabolic bone diseases, J. Bone Miner. Res. 7, 1243-1250 (1992).Shouki YatsushiroCompleted the doctorate course at the Graduate School of Natural Sciences and Technology, Okayama University in 2001. Doctor (Pharmacology). After working as a Research Fellow (PD), Japan Society for the Promotion of Science, and as assistant professor at the School of Pharmacy, Shujitsu University, joined the Health Technology Research Center, AIST Shikoku as a researcher in 2007. Researcher in Health Research Institute, AIST from 2010. Currently engages in the research for the infectious disease biomarkers and for the device for rapid diagnosis of infectious disease using the microchip. In this paper, worked on the antibody selection and investigated its optimal labeling method.Shohei YamamuraCompleted the doctorate course at the School of Material Science, Japan Advanced Institute of Science and Technology in 2002. Doctor (Material Science). Worked as a post-doctoral researcher in the Toyama Medial Biocluster, Knowledge Cluster Initiative, Ministry of Education, Culture, Sports, Science and Technology, and as an assistant professor of the School of Material Science, Japan Advanced Institute of Science and Technology. Joined the Health Technology Research Center, AIST Shikoku as a researcher in 2008. Researcher in Health Research Institute, AIST from 2010. Currently engages in R&D of the cell chip for the construction of diagnostic system of various diseases including infections. In this paper, designed the micro flow channel and constructed the antibody fixing method.Masato TanakaJoined the Shikoku National Research Institute, Agency of Industrial Science and Technology, Ministry of International Trade and Industry in 1988. Engaged in research for the mechanical system control and the measurement technology using ultrasound. Became a senior researcher of AIST in 2001. Doctor (Engineering) from The University of Tokushima in 2002. Senior researcher of the Biodevice Team, Health Technology Research Center, AIST Shikoku from 2005. Senior researcher in Health Research Institute, AIST from 2010. Currently studies the microfabrication technology and the ultralow-volume droplet control technology for biodevice construction. In this paper, worked on the discharge and fixing of antibody using the miniaturized inkjet.Toshihiko OoieCompleted the doctorate course at the Graduate School of Engineering, Osaka University in 1993. Doctor (Engineering). Jointed the Shikoku National Research Institute, Agency of Industrial Science and Technology, Ministry of International Trade and Industry as a researcher in 1993. Became the Senior Research Officer in 1997. Became a senior researcher at AIST in 2001. Became the leader of the Biodevice Team, Health Technology Research Center, AIST Shikoku in 2005.

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