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Research paper : Expansion of organic reference materials for the analysis of hazardous substances in food and the environment (T. Ihara et al.)−19−Synthesiology - English edition Vol.2 No.1 (2009) it satisfies the market demand for the uncertainty levels in working RMs.6 Issues for further studyWe envision a transfer from the current one-to-one traceability system based on separate national RMs for each substance, to one-to-many traceability system in which several substances can be traced to just a few national RMs. So far, we made advancement for the development of universal calibration technology, a core technology applicable to numerous organic compounds. After establishing an ideal scenario for this project, we began by developing elemental technologies, using irradiation pulse delay time and optimization of audio filters. We then demonstrated that these calibration technologies could satisfy market requirements for uncertainty. We learned that the transfer materials could be used to minimize the number of national RMs required as standards for amount-of-substance. Finally, we plotted a roadmap toward an efficient traceability system, as illustrated in Fig. 8.The system we outlined represents a quantum leap in the efficiency of traceability systems, since it removes the need to maintain one-to-one traceability chain from national RMs to working RMs for individual substances. It is an entirely new approach to RMs, unseen elsewhere in the world. The novelty of this technology, however, means that it is necessary to conduct numerous proving tests and to publish the results. The quantitative NMR technique must be standardized as an analytical method, and new international comparisons will be required at national metrology institutes Calibration by quantitative NMRCalibration by quantitative NMRpoint depression methodCalibration by freezingSubstance ZSubstance YSubstance CSubstance BSubstance AWorking RMTransfer materialPrimary standardNational RMInternational system of unit (SI)Substance XFutureCurrentAccurate estimationof active substancescontentActive substancesSufficient evaluationby quantitative NMRIsolationNatural sourcesInaccurate estimationof active substancescontentInsufficientevaluation99.699.899.999.799.899.799.799.799.699.799.899.999.899.899.60.20.20.10.20.30.40.30.30.30.30.20.20.20.30.399.599.999.399.299.599.199.699.399.999.899.999.399.899.699.299.599.799.499.899.599.50.60.50.50.80.60.50.50.31.20.70.60.50.70.60.60.30.70.70.70.70.5(%)k(%, =2)(%)(%, =2)k---------------------------------------- -Nonachlor -NonachlorOxychlordaneEndrin -Chlordane -ChlordaneTrichlorfon (DEP)Heptachlor4,4'-DDT4,4'-DDE4,4'-DDDProcymidoneFenobucarb (BPMC)Fenitrothion (MEP)α-HCHβ-HCHAtrazineEPNDiazinonMalathionEtofenproxtranscistranscisddddddddddddddddddddddddddInapplicable(thermal decomposition)Inapplicable(thermal decomposition)Inapplicable(Uncrystallized)Inapplicable(Uncrystallized)Inapplicable(Uncrystallized)Inapplicable(Uncrystallized)Benzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidBenzoic acidDimethyl sulfoneDimethyl sulfoneDimethyl sulfoneDimethyl sulfone1,4-BTMSB- 41,4-BTMSB- 4----------1,4-BTMSB- 41,4-BTMSB- 41,4-BTMSB- 4-----Dimethyl sulfoneSolventTransfer materialPrimary standardUncertaintyAnalytical valueReference valueQuantitative NMRFreezing point depression methodTerget substanceUncertaintyAcetone- 6Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Acetonitrile- 3Acetonitrile- 3Acetonitrile- 3Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Dichloromethane- 2Inapplicable(thermal decomposition)Inapplicable(Uncrystallized)Inapplicable(thermal decomposition)Inapplicable(Uncrystallized)Inapplicable(Uncrystallized)Inapplicable(Uncrystallized)Table 2 Purity analysis results for organic compounds using quantitative NMR.Fig. 8 Efficient traceability system with quantitative NMR.Fig. 9 Quantitative evaluation of active substances in natural sources using quantitative NMR.

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