Vol.1 No.3 2009

24/69

Research paper : Development of massive synthesis method of organic nanotube toward practical use (M. Asakawa et al.)−175 Synthesiology - English edition Vol.1 No.3 (2009) of nanofibers through self-organization of, for example, dual-headed glycolipids and aromatic amides. Developed asymmetrical interior/exterior surfaces of organic nanotubes and selective modification of their interior surfaces. Currently planning elemental technology to determine the physical properties and practical applications of nanospaces within organic nanotubes. In this paper, worked on the molecular design and synthesis technology of amphiphilic molecules.Hiroyuki MinamikawaAfter joining the Research Institute for Polymers and Textiles, AIST, in 1988, worked on molecular design and synthesis, lipid molecule assembly, liquid crystal structures, functional analysis, and colloid chemistry using functional lipids (e.g., glycolipids). Currently working on interactions between lipid assemblies and biomacromolecules. In this paper, worked on the structural correlation assessment and property assessment based on the molecular design of the organic nanotubes.Toshimi ShimizuJoined the Research Institute for Polymers and Textiles, AIST, in 1977. Head of the Nanoarchitechtonics Research Center, AIST, from 2001. Coordinator of the Nanoarchitechtonics Research Center from 2008. Worked as a researcher representative of JST-CREST and JST-SORST of the Industrial Science and Technology Frontier Program from 1996, and has made a steady effort to pioneer and develop bottom-up nanotechnology. In this paper, worked as research coordinator for optimizing the molecules for fabricating the organic nanotubes and their nanobiological applications.Discussion with Reviewers1 Thinking on the range of R&D that should be done by AIST leadershipQuestion (Kazuo Igarashi)Item (5) of Figure 4 is Product Realization technology, but after reading the paper to the end, I see only mention of technological transfer policy for Product Realization. Please explain the positioning of Product Realization as described here and the range of R&D that should be done by AIST as perceived by the Authors.Answer (Masumi Asakawa)In Figure 4, the transfer of the contributions from the AIST to the companies is expressed as a color change from yellow to green. We believe that Product Realization in stage (5) should be performed primarily by the companies. Therefore, in this paper, we discuss the need to establish a technological transfer policy and research management system that enables rapid Product Realization by the companies after phases (3) and (4).Therefore, the issue remains regarding the extent of AIST’s involvment in certain phases, but, because we believe that the companies should take initiative in Product Realization, in this paper we describe the phases immediately prior to Product Realization.2 Measures against nano-risk for organic nanotubeQuestion (Kazuo Igarashi)On safety assessment technology in Figure 4, it is written: “Existing information using conventional assessment technologies and comparable assessment methods should be selected at the initial phase because there is very little room for the development of new technology.” However, I do not think assessment methods differ by each development phase. Does this mean the level of AuthorsMasumi AsakawaJoined the National Institute of Materials and Chemical Research, AIST, in 1996. Engaged in research on molecular elements and molecular assembly using supramolecular chemistry methods to study assembly function based on molecular interactions. After experiencing major responsibilities as head of the planning section in 2004, started the development and practical applications of the mass synthesis of organic nanotubes. In this paper, worked on the mass synthesis, safety assessment, utilization development, and promotion for practical use, and was in charge of the overall conceptualization.Masaru AoyagiJoined AIST in 2001. Worked on research into molecular recognition (self-assembly, inclusion chemistry) by monomolecular membranes at air-water interface and the development of related sensor systems. Recently worked on refining the organic nanotube synthesis and investigating and assessing phenomena (e.g., adhesion, release) caused by organic nanotubes and other substances. In this paper, worked on developing the synthesis process and practical applications.Naohiro KametaAfter joining the JST-SORST project, has worked on the development of chemical processes for tailor-made organic nanotubes that can include and release biomacromolecules (e.g., proteins, DNA) upon exterior stimulus. Also working to clarify the properties of nanospace, such as assessing the dynamic behavior and stability of protein inclusion in the cylindrical hollow spaces inside organic nanotubes. In this paper, worked on manufacturing the fluorescent organic nanotubes that may become major tools in the field of nanobiology.Masaki KogisoAfter joining the National Institute of Materials and Chemical Research, AIST, in 1995, has been working on research into one-dimensional nanostructure formation through self-organization of peptide lipids; i.e., forming nanostructures never seen in the world before, through simple methods, from simple compounds. As result, was the first to mass-produce organic nanotubes, leading to this full research project from basic research performed in the laboratory. Currently planning the construction of an organic nanotube library with various surface functional groups using a simple peptide lipid incorporating glycylglycine. In this paper, worked on the development of the mass synthesis and its practical uses.Mitsutoshi MasudaAfter joining the Research Institute for Polymers and Textiles, AIST, in 1992, worked on the functionalization through polymerization and formation of nanofibers and the preparation (21)−lipid and nanotube morphology, Langmuir, 21(2), 743-750 (2005).M. Asakawa and T. Shimizu: Yasuku te anzen koukinou na yuukinanochuubu (Inexpensive, safe and high performance organic nanotube), Mirai Zairyo, 7(10), 38-43 (2007) (in Japanese).Received original manuscript May 21, 2008Revisions received June 10, 2008Accepted June 10, 2008[15]

※このページを正しく表示するにはFlashPlayer9以上が必要です