Vol.1 No.3 2009

23/69

Research paper : Development of massive synthesis method of organic nanotube toward practical use (M. Asakawa et al.)−174 Synthesiology - English edition Vol.1 No.3 (2009) 6 Future issuesFor research into the practical use of organic nanotubes, a new material that has never been used in the world, we selected an open R&D method where utilization development was sought openly through material transfers, rather than a closed R&D method within a research institute, because we expected that applications would be possible in a wide range of fields. This approach became feasible after we had achieved the mass synthesis of organic nanotubes. At the same time, this mass synthesis enabled safety assessments to be performed at early stages of the R&D, enhancing the potential for practical use of our organic nanotubes and helping to raise the awareness and acceptance by companies.In the future, based on feedback obtained from the companies that accepted our samples, we shall (i) extract elemental technologies for utilization development and investigate solutions and (ii) develop Product Realization Research through collaborations with these companies. Also, we shall seek out fields where markets might form quickly and slowly. In the quick fields, we must prepare a system for supply to meet demand; in the slow fields, we must conduct R&D to accelerate the process through collaborations with universities. In particular, for the creation of a new industry, we must consider the development of new safety assessment methods and industrial standards for organic nanotubes, and we shall continue R&D through collaborations with practitioners in related fields and to collect/accumulate necessary information. Also, based on the concept of minimal manufacturingNote 2), we shall refine the synthetic method for the preparation of the organic nanotubes and create a new industry through the practical application of organic nanotubes by providing high added value through efficient synthesis, process development, and size control.AcknowledgementsThis study was conducted as part of a joint research project between the AIST and the Japan Science and Technology Agency (JST) through the “Core Research for Evolutional Science and Technology (CREST), 2000~2005” project and the subcontracted “Solution Oriented Research for Science and Technology (SORST), 2005~2008” research project.NotesNote 1) Tests were subcontracted to specialized testing organizations; they were conducted according to the following methods:Biodegradation tests: “Biodegradation Test of Chemical Substance by Microorganism” in Methods of Testing New Chemical Substances, CSCL.Oral acute toxicity tests using rats: “On Guidelines for Single and Multiple Dose Toxicity Test,” appendix to Guideline for Toxicity Test for Drugs and “On Revisions to Guidelines for Single and Multiple Dose Toxicity Test.”Ecotoxiciy tests: For acute toxicity tests of fish, “Fish, Acute Toxicity Test,” OECD Guideline for Testing of Chemicals 203 (1992); for the sea flea, “Daphnia sp., Acute Immobilization Test,” OECD Guideline for Testing of Chemicals 202 (2004); for algae growth inhibition tests, “Freshwater Algae and Cyanobacteria Growth Inhibition Test,” OECD Guideline for Testing of Chemicals 201 (2006).Note 2) National Institute of Advanced Industrial Science and Technology: Part III 3: Nanotechnology, Material, and Manufacturing Fields, Kenkyu Senryaku (Phase 2 Research Strategy 2008). http://www.aist.go.jp/aist_j/information/strategy_revise.html(20)−References[1][2][3][4][5][6][7][8][9][10][11][12][13][14]T. Shimizu, M. Masuda and H. Minamikawa: Supramolecular nanotube architectures based on amphiphilic molecules, Chem. Rev., 105(4), 1401-1443 (2005).The Society of Cyclodextrins, Japan (ed.): Nanomateriaru shikurodekisutorin (Nanomaterial Cyclodextrin), Sangyo Tosho, 203-218 (2005) (in Japanese).B. Yang, S. Kamiya, K. Yoshida and T. Shimizu: Confined organization of Au nanocrystals in glycolipid nanotube hollow cylinders, Chem. Commun., 500-501 (2004).B. Yang, S. Kamiya, Y. Shimizu, N. Koshizaki and T. Shimizu: Glycolipid nanotube hollow cylinders as substrates: Fabrication of one-dimensional metallic-organic nanocomposites and metal nanowires, Chem. Mater., 16(14), 2826-2831 (2004).H. Yui, Y. Shimizu, S. Kamiya, M. Masuda, I. Yamashita, K. Ito and T. Shimizu: Encapsulation of ferritin within a hollow cylinder of glycolipid nanotubes, Chem. Lett., 34(2), 232-233 (2005).H.W. Kroto, J.R. Heath, S.C. O’Brien, R.F. Curl and R.E. Smalley: C60: Buckminsterfullerene, Nature, 318, 162-163 (1985).S. Iijima: Helical microtubules of graphitic carbon, Nature, 354, 56-58 (1991).N. Nakashima, S. Asakuma, J.M. Kim and T. Kunitake: Helical superstructures are formed from chiral ammonium bilayers, Chem. Lett., 13(10), 1709-1712 (2005).K. Yamada, H. Ihara, T. Ide, T. Fukumoto and C. Hirayama: Formation of helical super structure from single-walled bilayers by amphiphiles with oligo-l-glutamic acid-head group, Chem. Lett., 13(10), 1713-1716 (2005).P. Yager and P.E. Schoen: Formation of tubules by a polymerizable surfactant, Mol. Cryst. Liq. Cryst., 106(3-4), 371-381 (1984).Y. Nishimiya, Y. Mie, Y. Hirano, H. Kondo, A. Miura and S. Tsuda: Mass preparation and technological development of an antifreeze protein, Synthesiology English Edition, 1(1), 7-14 (2008).M. Ada, K. Ishibashi, T. Negami and M. Sekiya; Nanotekunorojii no shakaijuyou (Social acceptance of nanotechnology), NTS (2006) (in Japanese).G. John, M. Masuda, Y. Okada, K. Yase and T. Shimizu: Nanotube formation from renewable resources via coiled nanofibers, Adv. Mater., 13(10), 715-718 (2001).S. Kamiya, H. Minamikawa, J.H. Jung, B. Yang, M. Masuda and T. Shimizu: Molecular structure of glucopyranosylamide

※このページを正しく表示するにはFlashPlayer9以上が必要です