AIST - Organization and Outline -

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Research Center for Stem Cell EngineeringToward establishing stem cell techniques as the basis for regenerative medicine and drug development and creating a stem cell industryURL : http://unit.aist.go.jp/scrc/cie/index_en.htmlE-mail : stemcell_c-ml@aist.go.jpAIST Tsukuba Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan Tel: (029) 861-2529 / Fax: (029) 861-2987 (from outside Japan: Tel: +81-29-861-2529 / Fax: +81-29-861-2987)【 Research Base 】 AIST Tsukuba (Central)The application of cells, tissues, and organs developed from multipotent stem cells to drug discovery screening and regenerative medicine in recent years is expected to become a next-generation innovation ensuring good health and security. In order to realize this expectation, we are developing techniques to establish embryonic stem cell lines and separate stem cells to obtain standardized stem cell sources. We are also developing techniques to effectively differentiate stem cells and create desired cell types, as well as a drug discovery screening system using the created cell types. Through these research activities, we will develop basic technologies to accelerate the practical application of stem cells.【 Director 】 Makoto Asashima【 Deputy Director 】Mahito Nakanishi【 Outline 】【 AIST Participating Technology Research Association 】Stem Cell Evaluation Technology Research AssociationBiomedicinal Information Research CenterDevelopment of next-generation infrastructures in drug discovery and bioscienceURL : http://unit.aist.go.jp/birc2/english/E-mail : contact-birc-ml@aist.go.jp2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan Tel: (03) 3599-8100 / Fax: (03) 5530-2064 (from outside Japan: Tel: +81-3-3599-8100 / Fax: +81-3-5530-2064)【 Research Base 】 AIST Tokyo WaterfrontOur mission is to develop innovative basic technologies and resources for drug discovery research in the post-genome era. To accomplish this, we have developed an ultrasensitive mass spectrometry system to identify protein interactions relevant to diseases. Analyzing structures of membrane proteins and other disease-related proteins would lead to “structure guided drug discovery”. Our resources of natural compounds are used to identify new drug candidates that regulate functions of those disease-related proteins. Non-coding RNA is a novel target of drug discovery, and we are developing new technologies towards that direction. Our high quality full-length human cDNA library and protein array system are useful not only in drug discovery studies, but also in identification of genes that regulate de-differentiation and differentiation of cells, as well as in development of novel diagnostic systems. Finally, we are continuously updating and improving the annotated integrated database of all human genes, and making it publicly accessible. This would contribute to progress in drug discovery and life science in general.Basic drug discovery technologies【 Director 】 Ichio Shimada【 Deputy Director 】Taro Uyeda【 Deputy Director 】Junichi Sugai【 Outline 】【 AIST Participating Technology Research Association 】Epigenomics Technology Research AssociationTechnology Research Association for Next generation natural products chemistry�����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������(����������������������� �����������������������������������【 Deputy Director 】Masashi Suzuki Human iPS cells generated with Sendai virus vector SeVdp-iPSPancreatic tissue cells differentiated from ES cells(Green: Pancreatic beta cells expressing insulin, Red: Exocrine cells expressing amylase, Blue: Nucleus)Human bone marrow-derived mesenchymal stem cellsBeating cardiomyocytes differentiated from ES cells22Organization and OutlineLife Science and Biotechnology

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