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研究論文:糖鎖研究のための基盤ツール開発およびその応用と実用化(成松)−201−Synthesiology Vol.5 No.3(2012)Sato, H. Ito, K. Tachibana, T. Kubota, T. Noce, H. Narimatsu and Y. Zhang: Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile, Biochem. Biophys. Res. Commun., 402(4), 680-686 (2010).T. Sato, M. Gotoh, K. Kiyohara, T. Akashima, H. Iwasaki, A. Kameyama, H. Mochizuki, T. Yada, N. Inaba, A. Togayachi, T. Kudo, M. Asada, H. Watanabe, T. Imamura, K. Kimata and H. Narimatsu: Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate, J. Biol. Chem., 278(5), 3063-3071 (2003).T. Sato, M. Gotoh, K. Kiyohara, A. Kameyama, T. Kubota, N. Kikuchi, Y. Ishizuka, H. Iwasaki, A. Togayachi, T. Kudo, T. Ohkura, H. Nakanishi and H. Narimatsu: Molecular cloning and characterization of a novel human 1,4-N-acetylgalactosaminyltransferase, 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc 1-4GlcNAc, J. Biol. Chem., 278(48), 47534-47544 (2003).T. Sato, M. Sato, K. Kiyohara, M. Sogabe, T. Shikanai, N. Kikuchi, A. Togayachi, H. Ishida, H. Ito, A. Kameyama, M. Gotoh and H. Narimatsu: Molecular cloning and characterization of a novel human 1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain, Glycobiology, 16(12), 1194-1206 (2006).A. Togayachi, T. Akashima, R. Ookubo, T. Kudo, S. Nishihara, H. Iwasaki, A. Natsume, H. Mio, J. Inokuchi, T. Irimura, K. Sasaki and H. Narimatsu: Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide 1,3-N-acetylglucosaminyltransferase (3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids, J. Biol. Chem., 276(25), 22032-22040 (2001).A. Togayachi, N. Kikuchi, T. Kudo and H. Narimatsu: Comprehensive study on glycosyltransferases which determine glycosylation, Tanpakushitsu Kakusan Koso, 48(11 Suppl), 1542-1549 (2003).A. Togayachi, T. Sato and H. Narimatsu: Comprehensive enzymatic characterization of glycosyltransferases with a 3GT or 4GT motif, Methods Enzymol., 416, 91-102 (2006).H. Wang, K. Tachibana, Y. Zhang, H. Iwasaki, A. Kameyama, L. Cheng, JM. Guo, T. Hiruma, A. Togayachi, T. Kudo, N. Kikuchi and H. Narimatsu: Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14, Biochem. Biophys. Res. Commun., 300(3), 738-744 (2003).T. Yada, M. Gotoh, T. Sato, M. Shionyu, M. Go, H. Kaseyama, H. Iwasaki, N. Kikuchi, YD. Kwon, A. Togayachi, T. Kudo, H. Watanabe, H. Narimatsu and K. Kimata: Chondroitin sulfate synthase-2: molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities, J. Biol. Chem., 278(32), 30235-30247 (2003).T. Yada, T. Sato, H. Kaseyama, M. Gotoh, H. Iwasaki, N. Kikuchi, YD. Kwon, A. Togayachi, T. Kudo, H. Watanabe, H. Narimatsu and K. Kimata: Chondroitin sulfate synthase-3: molecular cloning and characterization, J. Biol. Chem., 278(41), 39711-39725 (2003).Y. Zhang, H. Iwasaki, H. Wang, T. Kudo, T.B. Kalka, T. Hennet, T. Kubota, L. Cheng, N. Inaba, M. Gotoh, A. Togayachi, J. Guo, H. Hisatomi, K. Nakajima, S. Nishihara, M. Nakamura, J.D. Marth and H. Narimatsu: Cloning and characterization of a new human UDP-N-acetyl--D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc -serine/threonine antigen, J. Biol. Chem., 278(1), 573-584 (2003).K. Amano, Y. Chiba, Y. Kasahara, Y. Kato, M.K. Kaneko, A. Kuno, H. Ito, K. Kobayashi, J. Hirabayashi, Y. Jigami and H. Narimatsu: Engineering of mucin-type human glycoproteins in yeast cells, Proc. Natl. Acad. Sci., 105(9), 3232-3237 (2008).H. Ito, A. Kuno, H. Sawaki, M. Sogabe, H. Ozaki, Y. Tanaka, M. Mizokami, J. Shoda, T. Angata, T. Sato, J. Hirabayashi, Y. Ikehara and H. Narimatsu: Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools, J. Proteome Res., 8(3), 1358-1367 (2009).M.K. Kaneko, Y. Kato, A. Kameyama, H. Ito, A. Kuno, J. Hirabayashi, T. Kubota, K. Amano, Y. Chiba, Y. Hasegawa, I. Sasagawa, K. Mishima and H. Narimatsu: Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor, FEBS Lett., 581(2), 331-336 (2007).Y. Kato, M.K. Kaneko, A. Kuno, N. Uchiyama, K. Amano, Y. Chiba, Y. Hasegawa, J. Hirabayashi, H. Narimatsu, K. Mishima and M. Osawa: Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain, Biochem. Biophys. Res. Commun., 349(4), 1301-1307 (2006).H. Ito, A. Kameyama, T. Sato, K. Kiyohara, Y. Nakahara and H. Narimatsu: Molecular-weight-tagged glycopeptide library: efficient construction and applications, Angew. Chem. Int. Ed., 44(29), 4547-4549 (2005).H. Ito, A. Kameyama, T. Sato, M. Sukegawa, H.K. Ishida and H. Narimatsu: Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly, Nat. Methods, 4(7), 577-582 (2007).H. Kaji, H. Saito, Y. Yamauchi, T. Shinkawa, M. Taoka, J. Hirabayashi, K. Kasai, N. Takahashi and T. Isobe: Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins, Nat. Biotechnol., 21(6), 667-672 (2003).H. Kaji, Y. Yamauchi, N. Takahashi and T. Isobe: Mass spectrometric identification of N-linked glycopeptides using lectin-mediated affinity capture and glycosylation site-specific stable isotope tagging, Nat. Protoc., 1(6), 3019-3027 (2006).A. Kuno, Y. Kato, A. Matsuda, M.K. Kaneko, H. Ito, K. Amano, Y. Chiba, H. Narimatsu and J. Hirabayashi: Focused differential glycan analysis with the platform antibody-assisted lectin profiling for glycan-related biomarker verification, Mol. Cell Proteomics, 8(1), 99-108 (2009).A. Kuno, A. Matsuda, Y. Ikehara, H. Narimatsu and J. Hirabayashi: Differential glycan profiling by lectin microarray targeting tissue specimens, Methods Enzymol., 478, 165-179 (2010).H. Narimatsu, H. Sawaki, A. Kuno, H. Kaji, H. Ito and Y. Ikehara: A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics, FEBS J., 277(1), 95-105 (2010).A. Kuno, Y. Ikehara, Y. Tanaka, T. Angata, S. Unno, M. Sogabe, H. Ozaki, K. Ito, J. Hirabayashi, M. Mizokami and H. Narimatsu: Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray, Clin. Chem., 57(1), 48-56 (2011).A. Kuno, Y. Ikehara, Y. Tanaka, K. Saito, K. Ito, C. Tsuruno, [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]

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