How to improve the specific power density of the rechargeable lithium ion battery has recently become one of the most attractive topics of both scientific and industrial interests. The spinel LiMn₂O₄ is the most promising candidate as a cathode material because of its low cost and nontoxicity compared with commercial LiCoO₂. Moreover, nano-structured electrodes have been widely investigated to satisfy such industrial needs. Among all of the nano-structures, single crystalline nanowire is the most attractive morphology because the nonwoven fabric morphology constructed by the single crystalline nanowire suppresses the aggregation and grain growth at high temperature, and the potential barrier among the nanosize grains can be ignored. Here we first synthesized high quality single crystalline cubic spinel LiMn₂O₄ nanowires based on a novel reaction method using Na_0.44MnO₂ nanowires as self-template. These single crystalline spinel LiMn₂O₄ nanowires show excellent performance at high rate charge-discharge process such as 100C with both a relative flat charge-discharge plateau and excellent cycle stability.