We have successfully developed a novel matrix-free soft ionization mass spectrometry technique. In this technique, by irradiating laser shots on the sample simply deposited on germanium quantum dots, mass spectra can be easily observed without obstructive peaks. So far, highly sensitive analysis at 10-16 mol level for peptides and analysis of brominated flame-retardants have been demonstrated. This technique is further applicable for wide range of samples not only biomaterials such as proteins, peptides and oligosaccharaides, but also industrial materials such as synthetic polymers and additives.