Silica solid is prepared by a novel sol-gel type method using silane alkoxide and acid anhydride instead of water. This synthetic procedure is performed in organic solution media, which is advantageous to make homogeneous systems of the precursors of silica and organic compounds. This procedure readily produced an epoxy resin/silica nanocomposite material, which had no Tg point under 300°C. On the other hand, when silica was prepared in the presence of dissolving cholesterol, silica obtained adsorbed steroid hormones such as progesterone more predominantly than other analogous compounds, probably due to the molecular imprinting effect of cholesterol.