The development of environmental friendly alternatives to prevent the depletion of the ozone layer and global warming is necessary for a sustainable society. In this research, 6 HFEs (Hydrofluoroethers) have been developed as new alternative cleaning agents. These HFEs were selected out of 88 compounds by various evaluations such as physical properties, toxicity and atmospheric life time. Also, we developed an efficient synthetic process of HFEs using water as a solvent in the addition reaction of alcohol to fluorinated olefin.

HFE-347pc-f (CHF₂CF₂OCH₂CF₃) has been already commercialized, and its use will be extended further.