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Microorganisms have adapted themselves to a variety of environments and acquired various functions over the past 3.5 billion years of biological evolution. Although many microbial functions have been utilized so far, it is said that more than 90 of the microbes in nature still remains untouched.By clarification of microbial functions, such as microbial diversity, symbiosis and multimicrobial system, we are striving to develop new bioresources. In addition to these, we are developing an experimental evolution system to create enzymes having new functions. This basic R&D is expected to create a new technology system clean and in harmony with nature.